
European colonization of the Americas nearly obliterated the populations and cultures of the Native Americans. During the 16th through 19th centuries, their populations were ravaged by conflicts with European explorers and colonists, disease, displacement, enslavement, internal warfare as well as high rate of intermarriage. Scholars now believe that, among the various contributing factors, epidemic disease was the overwhelming cause of the population decline of the American natives.
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Wiki: Native Americans in the United States
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